Comparative study of chemical composition and the antimutagenic activity of propolis extracts obtained by means of various solvents

The present study is aimed to evaluate the chemical characterization and antimutagenic potential of propolis extracted in three different solvents (ethanol, polyethylene glycol water). properties extracts were identified using HPLC-DAD LC?MS/MS extract found be richer than ethanolic water considering composition. In addition, activities determined Ames assay. concentrations 3, 1.5 0.75 mg plate-1 extracts, as well 0.3, 0.15 ? 0.075 used active materials. Propolis indicated strong activity against both 4-nitro- -o-phenylendiamine sodium azide mutagens Salmonella typhimurium TA98 100 strains at all concentrations. Ethanolic had highest inhibition rates for bacterial these 98.94 97.37 % TA100, respectively. ranged from 68.27 98.94%. Moreover, it was that lowest rates, which 56.86 55.35% toxicological safety natural products such has gained great importance due extensive usage.